PAH Metabolites | Skaggs School of Pharmacy Mass Spectrometry Core

Hydroxylated PAH analytes

Select an analyte below to review its parent PAH, official abbreviation, CAS number, and analytical context. Open the graphic for a structural metabolism overview.

Measurement scope*The hydroxyfluorene isomers cannot be chromatographically separated and are reported as combined 2-, 3-, and 9-hydroxyfluorene. All three compounds are included in the assay list, but individual isomer concentrations are not reported.

PAH hydroxylation and measured metabolites

The diagram groups hydroxylated targets under their parent PAHs. It is a simplified metabolic relationship map; hydroxylation may require multiple enzyme systems and subsequent conjugation. Highlighted nodes represent reportable assay results.

Parent PAH · not measured by this assay

Naphthalene

2-ring parent PAH

Parent PAH · not measured by this assay

Fluorene

3-ring parent PAH

Parent PAH · not measured by this assay

Phenanthrene

3-ring parent PAH

Parent PAH · not measured by this assay

Pyrene

4-ring parent PAH

Parent PAHs are unmeasured context. The hydroxyfluorene isomers share one combined result because this method does not separate them chromatographically. Relative amounts for individual hydroxyfluorene isomers cannot be determined from that result.

Selected measurement

Parent compound and metabolic relationship

Analytical and biological context

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The listed hydroxylated PAHs are interpreted as indicators of PAH-related exposure, with matrix, collection time, metabolism, and other sources influencing interpretation. See the measurement note for the hydroxyfluorene reporting limitation.

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